230 Mellon Hall
201 Mellon Hall
600 Forbes Ave.
Pittsburgh, PA 15282
University of Pittsburgh, Department of Microbiology & Molecular Genetics; Hillman Cancer Center (Galson Laboratory)
Philip E. Auron, PhD
Professor, Department of Biological Sciences
Bayer School of Natural and Environmental Sciences
The Auron lab focuses on molecular gene regulation of immunologically relevant molecules, especially Toll-Like Receptor pro-inflammatory induction in monocytes and other myeloid cells. Cellular signal transduction, gene regulation (Especially RNA Polymerase II Transcription Initiation; and transcription factor regulation and function).
Technique Expertise or Resources to share
Monocyte and macrophage cell culture using primary human and mouse cells and established cell lines. The primary assays are: mRNA RT-PCR; ChIP-PCR; 3C/Chromatin Conformational Capture; protein-protein interaction assays; live-cell widefield & confocal fluorescence microscopy; Normoxic & Hypoxic cell-culture; Bio-informatics (especially transcription factor searches and sequence homology); 3-D molecular structure analysis, docking & molecular dynamics.
Interleukin 1β; IL1B gene; Spi-1/PU.1; C/EBPβ
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