Stephen F. Badylak, DVM, PhD, MD

PCIBMR Bioengineered Models Core Co-Director

Professor, Departments of Surgery and Bioengineering
Deputy Director, McGowan Institute for Regenerative Medicine
University of Pittsburgh

Research Interests

Biologic Scaffolds and Extracellular Matrix Biology

Biomaterials and Host-Biomaterial Interactions

Role of Innate Immune Response in Tissue Engineering and Regenerative Medicine

Limb and Digit Regeneration

Applications of ECM Bioscaffolds to CNS, GI, whole organ, ocular, musculoskeletal, and UG systems.

Role of Matrix-bound Nanovesicles (MBV) on Inflammation and Healing

Technique Expertise or Resources to share

Technique Expertise:

• preparing decellularized tissues and characterization of the biochemical properties
• Immunolabeling techniques for quantification of tissue remodeling in limb and digit regeneration
• Image analysis and spatial quantification of histologic images

Resources (specific to bone and mineral research):
 

• Supercritical CO2 system for sterilization and decellularization of bone
• Laser Capture Microdissection System / Molecular Machines & Industries mmi Cellcut
• Material Property Testing System / MTS Insight & Texture Technologies TA.XT Plus
• Low Oxygen Cell Culture System (custom made) / Biospherix
• Organ bath system for tissue and whole organ (heart) / Radnoti
• NanoCool Stem Cell injection & delivery system / Harvard Apparatus
• Microgravity bioreactors / Synthecon
• Zeiss AxioObserver Z1 fluroescence / DIC microscope with live cell imaging capabilities
• Leica DMB4000 TCS SPE spectral laser confocal system

Keywords

Biologic scaffolds, extracellular matrix