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Office Location:
Hillman Cancer Center
Research Pavilion G5.c

Mailing address:
5117 Centre Ave, Hillman Cancer Center, Research Pavilion G5.c


Phone: 412-623-2211

Brenda Atoo

Other Affiliations:

  • Genome Stability Program, Hillman Cancer Center
  • Molecular Pharmacology Graduate Program, University of Pittsburgh School of Medicine
  • Molecular Genetics and Developmental Biology Program, University of Pittsburgh School of Medicine


Wei Du, MD, PhD

Associate Professor, Department of Medicine, Division of Hematology-Oncology
University of Pittsburgh School of Medicine

Research Interests

My research is centered on pathophysiology of hematologic diseases such as bone marrow (BM) failure and leukemia. I have a broad background in hematopoiesis, stem cell biology & aging, cellular metabolism and tumor microenvironment, with specific training and expertise in DNA damage response/repair, mouse modeling, metabolite profiling, and in vivo disease modeling. I have been investigating the mechanism of hematopoietic stem cell (HSC) mobilization and BM niche engraftment as well as the factors implicated in cell proliferation and apoptosis. I have identified functional interactions between certain factors implicated in cell polarity, adhesion/migration, stem cell metabolism and aging. My lab is also interested in understanding the underlying mechanisms by which regulate bone development and hematopoietic supportive function of bone marrow cells.

Technique Expertise or Resources to share

Mouse mesenchymal stromal cell isolation and differentiation assays; Histology and immunofluorescence staining of mouse bones; Mesenchymal stromal cell-Hematopoietic stem progenitor cells coculuture assays etc. My lab has established several mouse models with the tissue specific gene deletion in different lineage of cells, such as osteoprogenitor cells, epithelial cells and mesenchymal stromal cells and so on.


Bone marrow microenvironment, mesenchymal stromal cells, osteogenesis, adipogenesis, DNA damage repair, hematopoiesis


Lab website:


Lab Members

Limei Wu Postdoctoral Fellow
Fabliha Chowdhury PhD student
Andrew Sinsheimer Postdoctoral Fellow