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Office Location:
940 Benedum Hall

Mailing address:
3700 O’Hara Street
Pittsburgh, PA 15261


Phone: 412-624-9614

Alice Liang

Other Affiliations:
Department of Bioengineering, School of Pharmacy, Department of Pharmaceutical Sciences, School of Medicine, Departments of Immunology, Ophthalmology, and the McGowan Institute for Regenerative Medicine


Steven R. Little, PhD

William Kepler Whiteford Professor and Chair
Department of Chemical Engineering
Swanson School of Engineering, University of Pittsburgh

Research Interests

The Little Lab explores synthetic delivery strategies that mimic those of cells and tissues in order to enhance (or alternatively endow new) functionality. Our group explores new ways to produce complex, temporo-spatial presentation of bio-active molecules to mimic natural biological context.  Specifically, we explore nano and micro fabrication techniques to promote proper spatial context. We intend to utilize this technology to modulate regulatory T-cells (Treg) and antigen presenting populations in the tumor microenvironment.  The Little lab has also explored the sequential delivery of growth factors to facilitate building new blood vessels. Further developed from the controlled release system, our group successfully fabricated CCL-22 releasing microparticles technology to treat inflammatory periodontal disease, these CCL-22MP dramatically reduced inflammation-induced symptoms without administration of antibiotics.

Technique Expertise or Resources to share

Beckman Coulter Multisizer
Malvern Zetasizer
Milli-Q Water Purification
Microparticle fabrication


Drug Delivery, Biomimetics, Targeted Immunosuppression, Thermoresponsive Hydrogel-microsphere, Controlled Release, Polymer


Lab website:


Lab Members

Stephen Balmert Postdoctoral Associate
Nihan Yonet-Tanyeri Postdoctoral Associate
Warren Sands Postdoctoral Associate
Elizabeth Bentley PhD Student Candidate
Matt Borrelli PhD Student Candidate
Ashlee Greene PhD Student Candidate
Julie Kobyra PhD Student Candidate
Andrea Schilling PhD Student Candidate
Benjamin Ahlmark Undergraduate Student Trainee
Reetwan Bandyopadhyay Undergraduate Student Trainee