Laura E. Pascal, PhD

Research Assistant Professor
Department of Pharmacology and Chemical Biology
University of Pittsburgh School of Medicine

Research Interests

Prostate cancer and benign prostatic hyperplasia are two age-related diseases which present a significant burden for older men in the US. Although BPH is not usually life-threatening, the mechanisms contributing to BPH are largely unknown which makes it difficult to develop successful BPH prevention and treatment strategies. Our research is focused on determining the role of aging and mitochondrial dysfunction on prostatic inflammation and bladder dysfunction.

Technique Expertise or Resources to share

We have generated and characterized a prostate luminal epithelial specific Cdh1 knockout mouse as a model of prostatic inflammation and bladder overactivity.

Keywords

Aging, benign prostatic hyperplasia, E-cadherin, NDUFS3, prostate cancer