Shadyside Medical Building, Suite G34
5200 Centre Ave, Pittsburgh, PA 15232
Hillman Cancer Center
Laura E. Pascal, PhD
Research Assistant Professor, Department of Urology
University of Pittsburgh School of Medicine
Prostate cancer and benign prostatic hyperplasia are two age-related diseases which present a significant burden for older men in the US. Although BPH is not usually life-threatening, the mechanisms contributing to BPH are largely unknown which makes it difficult to develop successful BPH prevention and treatment strategies. Our research is focused on determining the role of increased prostatic inflammation and decreased expression of epithelial barrier proteins such as E-cadherin and claudin-1 in the development of BPH and prostate cancer.
Technique Expertise or Resources to share
We have generated and characterized a prostate luminal epithelial specific Cdh1 knockout mouse as a model of prostatic inflammation and bladder overactivity.
Prostate cancer, aging, benign prostatic hyperplasia, E-cadherin, claudin-1