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Office Location:
Shadyside Medical Building, Suite G34

Mailing address:
5200 Centre Ave, Pittsburgh, PA 15232

Email: pascalle@upmc.edu

Phone: 412-623-3916

Other Affiliations:
Hillman Cancer Center

MEMBERS

Laura E. Pascal, PhD

Research Assistant Professor, Department of Urology
University of Pittsburgh School of Medicine

Research Interests

Prostate cancer and benign prostatic hyperplasia are two age-related diseases which present a significant burden for older men in the US. Although BPH is not usually life-threatening, the mechanisms contributing to BPH are largely unknown which makes it difficult to develop successful BPH prevention and treatment strategies. Our research is focused on determining the role of increased prostatic inflammation and decreased expression of epithelial barrier proteins such as E-cadherin and claudin-1 in the development of BPH and prostate cancer.

Technique Expertise or Resources to share

We have generated and characterized a prostate luminal epithelial specific Cdh1 knockout mouse as a model of prostatic inflammation and bladder overactivity.

Keywords

Prostate cancer, aging, benign prostatic hyperplasia, E-cadherin, claudin-1