Evan Ray, MD, PhD
Assistant Professor, Department of Medicine, Renal-Electrolyte Division
University of Pittsburgh School of Medicine
The Ray lab’s research focuses on mechanisms of mineral homeostasis, in particular Mg2+ and Ca2+. We are examining handling of these minerals by the kidney and intestines, the transporters involved, and the regulation of those transporters. Additionally, we are examining the consequences of Mg2+ and Ca2+ depletion, including effects on bone health and effects on progeny of mineral-depleted mothers.
Technique Expertise or Resources to share
We use cell culture to examine interaction of mineral transporters and regulatory proteins using biochemical techniques. We use genetically modified mice to elucidate the importance of different molecular participants in mineral handling. We phenotype these mice by measuring mineral concentrations in bodily fluids (urine, plasma, and breastmilk), western blot and ELISA to measure protein expression, and micro-CT to examine bone structure.
Magnesium, calcium, mucin, MUC1, Trp channel, ion channel, endocytosis, lactation, nursing, pregnancy, bone, osteoporosis, perinatal programming.
Lab website: https://www.rayrenal.com/
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