Samantha L. Rosenthal, PhD

Assistant Professor, Department of Oral and Craniofacial Sciences
Center for Craniofacial and Dental Genetics
University of Pittsburgh School of Dental Medicine

Research Interests

At the present, my work focuses on characterizing the function of the gene CREBRF in cellular metabolism and on gene expression, as well as identifying the mechanism(s) by which variation in this gene is associated with anthropometric phenotypes, such as height and body mass index (BMI). I also study the genetic associations of cardiometabolic traits in the Samoan population as a member of the Obesity, Lifestyle, and Genetic Adaptations (OLaGA, “life” in Samoan) study group (https://publichealth.yale.edu/olaga/).

Technique Expertise or Resources to share

RNA sequencing, whole genome sequencing (WGS) and whole exome sequencing (WES), genome wide association studies (GWAS), cell modeling. As new faculty, I do not yet have my own datasets, but am a member of the OLaGA research team, which has a whole genome genotype data (either genotype + imputed or WGS) and deep phenotyping data for a well-characterized cohort of Samoan individuals. No cell lines currently available, but will are planned to be developed in the next year.

Keywords

CREBRF, Samoa, OLaGA, genetics, gene expression, TOPMed, complex disease