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Office Location:
UPMC Presbyterian C602

Mailing address:
200 Lothrop St.
Pittsburgh, PA 15213


Phone: 412-647-9575

Other Affiliations:
PSARC (Pittsburgh Sarcoma Research Collaborative), USCAP


Karen E. Schoedel, MD

Professor of Pathology, Division of Anatomic Pathology
Director of the Bone and Soft Tissue Fellowship
University of Pittsburgh School of Medicine

Research Interests

I am interested in the genomic and immunologic aspects of bone neoplasms, particularly chondrosarcoma and the dedifferentiated variant.  I am also interested in understanding the process of dedifferentiation as applied to liposarcoma.

Technique Expertise or Resources to share

Histology, cytology, pathologic-radiologic correlation, interpretation of immunohistochemical stains, tissue micro-array.  My areas of pathology expertise include bone and soft tissue pathology, pancreatic cytology and thyroid cytology.

I have a set of dedifferentiated chondrosarcomas and liposarcomas with RNA sequencing data.

I created a master list of chondrosarcomas comprising the last 23 years of case material at UPMC including material that is being used by individual labs.

I also support researchers on request to provide interpretation of mouse and rabbit histology.


Sarcoma, chondrosarcoma, liposarcoma, bone repair and neoplasia

View Publications

Publication list 2019-20

Lopez L, Schoedel K, John I. Giant cell poor extra-articular diffuse type tenosynovial giant cell tumor with extensive desmin expression: A potential diagnostic pitfall with cytogenetic confirmation. Int J of Surgical Pathol. 2019; 27(1):59-61.

Lopez LV, Yatesnko SA, Burgess M, Schoedel K, Rao UNM. Dermatofibrosarcoma protuberans with fibrosarcomatous transformation: our experience, molecular evaluation of selected cases, and short literature review. Int J Dermatol. 2019 58(11): 1246-52.

Ohori NP, Landau MS, Carty SE, Yip L, Lebeau SO, Manroa P, Seethala RR, Schoedel KE, Nikiforova MN, Nikiforov YE. Benign Call Rate and Molecular Test Result Distribution of Thyroseq v3. Cancer Cytopathol 2019; 127 (3):161-8.

Rao U, Schoedel KE, Petrosko P, Sakai N, LaFramboise W. Genetic Variants and Copy Number Changes in Soft Tissue Leiomyosarcomas Detected by Targeted Amplicon Sequencing. J Clin Pathol 2019; 72(12):810-16.

Virginia Miller, Jason Shih Hoellwarth, Margaret Lydia Hankins, Richard McGough, and Karen Schoedel. Tumor-to-Tumor Metastasis: Prostate Carcinoma Metastatic to Soft Tissue Sarcoma, a Previously Unreported Event. International Journal of Surgical Pathology 2020; 28(2):196-99.

Patel A; Zaky SH; Schoedel K; Li H; Sant V; Beniash E; Sfeir C; Stolz DB; Sant S. Design and evaluation of collagen-inspired mineral-hydrogel nanocomposites for bone regeneration. Acta Biomaterialia. 2020 Jun 01.

Ma R; Mandell J; Lu F; Heim T; Schoedel K; Duensing A; Watters RJ; Weiss KR. Do Patient-derived Spheroid Culture Models Have Relevance in Chondrosarcoma Research?  Clinical Orthopaedics & Related Research. 2020 May 19.

Ohori NP; Landau MS; Manroa P; Schoedel KE; Seethala RR. Molecular-derived estimation of risk of malignancy for indeterminate thyroid cytology diagnoses. Journal of the American Society of Cytopathology JASC. 2020 Apr 08

Satturwar S, Pantanowitz L, Xing J, Schoedel K, Weber D, Monaco SE. Cytomorphology of Mycobacterium avium intracellulare-associated ascites. Diagnostic Cytopathology 2020 Jun 27

Patel A, Zaky SH, Li H, Schoedel K, Almarza AJ, Sfeir C, Sant V, Sant S. Bottom-up self-assembled hydrogel-mineral composities regenerate rabbit ulna defect without added growth factors. ACS Appl. Bio Mater 2020, 3, 9, 5652-5663.


UPMC Department of Pathology laboratories including the Molecular Anatomic Pathology and the Developmental Laboratory