Bing Wang, MD, PhD

Associate ​ Professor, Orthopaedic Surgery/Neurology
University of Pittsburgh School of Medicine

Research Interests

My research group has laid the groundwork for the proposed research by developing gene- and cell-based molecular techniques for in vivo and ex vivo gene transfer as well as biomaterial-mediated gene transfer for the treatment of musculoskeletal diseases such as bone healing. I have a long history of working on gene- and cell-based therapies for musculoskeletal injuries and diseases such as Duchenne muscular dystrophy, mainly by using viral vectors, and have extensive, published expertise and technology to develop these vectors for the basic and translational researches.

Technique Expertise or Resources to share

In currently proposed P30 Resource Center grant application for Bone, Muscle and Orthopaedic Research, we will provide a GENE CORE. The goal is to develop a customized three-dimensional bone construct with defect-matching architecture, consisting of a combination of nanoparticles, osteoinductive (BMP2) gene-modified stem cells and a body-friendly scaffold using projection stereolithography, which not only provides mechanical support and promotes bone growth, but also can directly accelerate osteogenesis to augment the repair outcome after craniofacial segmental bone defect.

Keywords

Osteo-inductive genes, viral vector gene expression system, gene- and cell-activated VL-PSL scaffold