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Office Location:
421 Mellon Hall​

Mailing address:
600 Forbes Ave
Pittsburgh, PA  15282

Email: wittp@duq.eduu

Phone: 412-396-4346

Nancy Hosni
Denise Veselic

Other Affiliations:
University of Pittsburgh Cancer Institute (UPCI)


Paula Witt-Enderby, PhD

Professor of Pharmacology, Division of Pharmaceutical Sciences
Duquesne University School of Pharmacy
University of Pittsburgh School of Medicine

Research Interests

The Witt-Enderby lab covers three main themes: (1) The molecular mechanisms underlying melatonin-mediated actions on osteoblastogenesis, osteoclastogenesis, and bone formation using human and mouse mesenchymal stem cells and rodent models with a focus on MAPK-mediated pathways. (2) Clinical studies assessing the efficacy of melatonin and weight-bearing exercise on markers of bone health, bone density and quality of life in healthy populations and those with osteopenia.  (3) Drug development with a focus on melatonin-based drug conjugates and hormone-based therapies targeted to enhancing the anti-cancer actions of existing drugs while reducing their adverse actions on bone, uterus, and sleep. For more information on past and current clinical trials, please see: Melatonin Osteoporosis Prevention Study, MOPS (NCT01152580); Melatonin-micronutrients Osteopenia Treatment Study, MOTS (NCT01870115); Herbal Teas on Bone Health in an Osteopenic Population, OsTea (NCT03480126); and Melatonin and Osteogenic Loading on Osteopenia, MelaOstrong Study (NCT04233112). 

Technique Expertise or Resources to share

Translational research; clinical trials; radioligand binding assays; western blots of lysates prepared from bone and cells; lncRNA and RNASeq; cell culture of monocultures and co-cultures of MSCs and peripheral blood monocytes and pre-osteoclasts; CRISPR Cas9


Melatonin, circadian rhythms, osteopenia, holistic medicine


Lab website:


Lab Members

Divya Shetty graduate student
Afsin Malik graduate student
Fahima Munmun graduate student